PPM1D (98-375, His-tag)

CAT#: AR51812PU-S

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Recombinant human PPM1D, fused to His-tag at N-terminus, was expressed in E.coli.


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USD 330.00


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2 Weeks

Size
    • 50 ug


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Product Data
Description Recombinant human PPM1D, fused to His-tag at N-terminus, was expressed in E.coli.
Species Human
Expression Host E. coli
Tag His-tag
Predicted MW 33.2 kDa
Concentration 0.5 mg/ml (determined by Bradford assay)
Purity > 85 % by SDS - PAGE
Buffer Liquid, In 20mM Tris-HCl (pH8.0) containing 10% glycerol.
Preparation Liquid purified protein
Reference Data
RefSeq NP_003611
Locus ID 8493
Cytogenetics 17q23.2
Synonyms IDDGIP; PP2C-DELTA; WIP1
Summary The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. The expression of this gene is induced in a p53-dependent manner in response to various environmental stresses. While being induced by tumor suppressor protein TP53/p53, this phosphatase negatively regulates the activity of p38 MAP kinase, MAPK/p38, through which it reduces the phosphorylation of p53, and in turn suppresses p53-mediated transcription and apoptosis. This phosphatase thus mediates a feedback regulation of p38-p53 signaling that contributes to growth inhibition and the suppression of stress induced apoptosis. This gene is located in a chromosomal region known to be amplified in breast cancer. The amplification of this gene has been detected in both breast cancer cell line and primary breast tumors, which suggests a role of this gene in cancer development. [provided by RefSeq, Jul 2008]
Protein Families Druggable Genome, Phosphatase
Protein Pathways p53 signaling pathway

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68 Mouse Clones