Glutamate dehydrogenase 1 (54-558, His-tag)

CAT#: AR51473PU-N

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Recombinant human GLUD1 protein, fused to His-tag at N-terminus, was expressed in E.coli.


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USD 820.00


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2 Weeks

Size
    • 500 ug


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Specifications

Product Data
Description Recombinant human GLUD1 protein, fused to His-tag at N-terminus, was expressed in E.coli.
Species Human
Expression Host E. coli
Tag His-tag
Predicted MW 58.4 kDa
Concentration 1.0 mg/ml (determined by Bradford assay)
Purity > 80 % by SDS - PAGE
Buffer 20 mM Tris-HCl buffer (pH 8.0) containing 0.4M Urea, 10% glycerol
Preparation Liquid purified protein
Reference Data
RefSeq NP_001305829
Locus ID 2746
Cytogenetics 10q23.2
Synonyms GDH; GDH1; GLUD
Summary This gene encodes glutamate dehydrogenase, which is a mitochondrial matrix enzyme that catalyzes the oxidative deamination of glutamate to alpha-ketoglutarate and ammonia. This enzyme has an important role in regulating amino acid-induced insulin secretion. It is allosterically activated by ADP and inhibited by GTP and ATP. Activating mutations in this gene are a common cause of congenital hyperinsulinism. Alternative splicing of this gene results in multiple transcript variants. The related glutamate dehydrogenase 2 gene on the human X-chromosome originated from this gene via retrotransposition and encodes a soluble form of glutamate dehydrogenase. Related pseudogenes have been identified on chromosomes 10, 18 and X. [provided by RefSeq, Jan 2016]
Protein Families Druggable Genome
Protein Pathways Alanine, aspartate and glutamate metabolism, Arginine and proline metabolism, D-Glutamine and D-glutamate metabolism, Metabolic pathways, Nitrogen metabolism

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68 Mouse Clones