Glutamate dehydrogenase 1 (54-558, His-tag)

CAT#: AR51473PU-N

Recombinant human GLUD1 protein, fused to His-tag at N-terminus, was expressed in E.coli.

Product images

Specifications

Product Data

• Description: Recombinant human GLUD1 protein, fused to His-tag at N-terminus, was expressed in E.coli.
• Species: Human
• Expression Host: E. coli
• Tag: His-tag
• Predicted MW: 58.4 kDa
• Concentration: 1.0 mg/ml (determined by Bradford assay)
• Purity: > 80 % by SDS - PAGE
• Buffer: 20 mM Tris-HCl buffer (pH 8.0) containing 0.4M Urea, 10% glycerol
• Preparation: Liquid purified protein

Reference Data

• RefSeq: NP_001305829
• Locus ID: 2746
• Cytogenetics: 10q23.2
• Synonyms: GDH; GDH1; GLUD
• Summary: This gene encodes glutamate dehydrogenase, which is a mitochondrial matrix enzyme that catalyzes the oxidative deamination of glutamate to alpha-ketoglutarate and ammonia. This enzyme has an important role in regulating amino acid-induced insulin secretion. It is allosterically activated by ADP and inhibited by GTP and ATP. Activating mutations in this gene are a common cause of congenital hyperinsulinism. Alternative splicing of this gene results in multiple transcript variants. The related glutamate dehydrogenase 2 gene on the human X-chromosome originated from this gene via retrotransposition and encodes a soluble form of glutamate dehydrogenase. Related pseudogenes have been identified on chromosomes 10, 18 and X. [provided by RefSeq, Jan 2016]
• Protein Families: Druggable Genome
• Protein Pathways: Alanine, aspartate and glutamate metabolism, Arginine and proline metabolism, D-Glutamine and D-glutamate metabolism, Metabolic pathways, Nitrogen metabolism