Hepatitis B Surface Antigen / HBsAg (ad) Human Protein

CAT#: AR31201PU-N

Hepatitis B Surface Antigen / HBsAg (ad) human protein, 1 mg

Specifications

Product Data

• Species: Human
• Protein Source: Blood
• Concentration: lot specific
• Purity: >99% “Ad” subtype purity (ELISA)
• Presentation: Purified
• Buffer: Presentation State: Purified
  State: Liquid purified fraction
  Buffer System: 50 mM Phosphate, pH 7.4 ± 0.2 containing 150 mM Sodium Chloride
  Preservative: 0.09% Sodium Azide
• Preparation: Liquid purified fraction
• Applications: ELISA.
• Protein Description: Hepatitis B Surface Antigen (HBsAg), ad subtype.
  Inactivation: Heat Inactivated at 60°C for 15 hours.
• Note: Caution: All human source materials have tested negative for HIV1, HIV2 and HCV antibodies. No test guarantees a product to be non-infectious. Therefore, all material derived from human fluids or tissues should be considered as potentially infectious.
• Storage: Store the antigen at 2-8°C.
• Stability: Shelf life: six months from despatch.

Reference Data

• Summary: Hepatitis B Virus (HBV) infection induces a disease state which manifests itself in a variety of ways, characterized by the extent of liver damage, inflammation and viral persistence. HBV infection is also associated with a 100 fold increased risk of hepatocellular carcinoma and currently infects over 250 million people worldwide. HBV has a partially double stranded 3.2 kilobase DNA genome which contains four open reading frames. One of these encodes a 154 amino acid protein called the HBx protein. HBx has been shown to be a transcriptional transactivator of both viral and cellular promoters. Lacking a DNA binding domain and nuclear localization signal, HBx is believed to exert transcriptional activity through protein protein interaction.