Gremlin-1 / GREM1 Mouse Protein

CAT#: AR26008PU-N

Gremlin-1 / GREM1 mouse recombinant protein, 50 µg

Product Images

Specifications

Product Data

• Species: Mouse
• Expression Host: E. coli
• Expression cDNA Clone or AA Sequence:
  Protein Sequence

  MKKKGSQGAI PPPDKAQHND SEQTQSPPQP GSRTRGRGQG RGTAMPGEEV LESSQEALHV TERKYLKRDW CKTQPLKQTI HEEGCNSRTI INRFCYGQCN SFYIPRHIRK EEGSFQSCSF CKPKKFTMMV TLNCPELQPP TKKKRVTRVK QCRCISIDLD
• Predicted MW: 28 kDa
• Purity: >95% by SDS-PAGE & Silver staining
• Presentation: Purified
• Buffer: Presentation State: Purified
  State: Lyophilized protein
  Buffer System: 50 mM acetic acid, without stabilizers
• Endotoxin: < 0.1 ng per μg of Grem1
• Reconstitution: Mouse Grem1 should be reconstituted in 50mM acetic acid or water to a concentration of 0.1 mg/ml. This solution can be diluted in water or other buffer solutions.
• Preparation: Lyophilized protein
• Protein Description: Recombinant mouse Gremlin-1 / GREM1, aa. 160
• Note: Protein RefSeq: NP_035954.1
  mRNA RefSeq: NM_011824
• Storage: The lyophilized protein is stable at room temperature for up to 1 week or at -20 °C for longer. Following reconstitution store (in aliquots) at -20 °C. Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.

Reference Data

• RefSeq: NP_035954
• Locus ID: 23892
• UniProt ID: O70326, Q3TNY7
• Cytogenetics: 2 57.43 cM
• Synonyms: Cktsf1b1; Drm; Grem; ld
• Summary: Cytokine that may play an important role during carcinogenesis and metanephric kidney organogenesis, as BMP a antagonist required for early limb outgrowth and patterning in maintaining the FGF4-SHH feedback loop (PubMed:12808456, PubMed:15201225). Down-regulates the BMP4 signaling in a dose-dependent manner (PubMed:15133038). Antagonist of BMP2; inhibits BMP2-mediated differentiation of osteoblasts (in vitro) (By similarity). Acts as inhibitor of monocyte chemotaxis (By similarity).[UniProtKB/Swiss-Prot Function]