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Malcavernin (His-tag) Human Protein

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SKU
AR26003PU-N
Malcavernin (His-tag) human recombinant protein, 20 µg
Size:
20 ug
  $300.00
2 Weeks*
Bulk/Customize

Other products for "CCM2 or NM_001029835"

Specifications
Specifications
Product Data
Species Human
Expression Host E. coli
Expression cDNA Clone or AA Sequence
Protein Sequence
MGSSHHHHHH SSGLVPRGSH MEEEGKKGKK PGIVSPFKRV FLKGEKSRDK KAHEKVTERR PLHTVVLSLP ERVEPDRLLS DYIEKEVKYL GQLTSIPGYL NPSSRTEILH FIDNAKRAHQ LPGHLTQHDA VLSLSAYNVK LAWRDGEDII LRVPIHDIAA VSYVRDDAAH LVVLKTAQDP GISPSQSLCA ESSRGLSAGS LSESAVGPVE ACCLVILAAE SKVAAEELCC LLGQVFQVVY TESTIDFLDR AIFDASTPTH HLSLHSDDSS TKVDIKETYE VEASTFCFPE SVDVGGASPH SKTISESELS ASATELLQDY MLTLRTKLSS QEIQQFAALL HEYRNGASIH EFCINLRQLY GDSRKFLLLG LRPFIPEKDS QFENFLETIG VKDGRGIITD SFGRHRRALS TTSSSTTNGN RATGSSDDRS APSEGDEWDR MISDISSDIE ALGCSMDQDS A
Tag His-tag
Purity >95% by SDS-PAGE and silver stain
Presentation State Purified
Buffer Presentation State: Purified
State: Lyophilized protein
Buffer System: PBS
Endotoxin < 0.1 ng/µg of CCM-2
Reconstitution Method The lyophilized protein is soluble in water and most aqueous buffers and should be reconstituted in PBS or medium containing at least 0.1% human or bovine serum albumin to a concentration not lower than 50 μg/ml.
Preparation Lyophilized protein
Protein Description Human recombinant Malcavernin (fragment), aa sequence: 464
Note Protein RefSeq: NM_001029835.2
mRNA RefSeq: NM_001029835.2
Storage Lyophilized samples are stable for six months at –20°C to –70°C. Reconstituted protein should be stored in working aliquots at -20°C. Avoid repeated freezing and thawing.
Stability Shelf life: one year from despatch.
Shipping Ambient
Reference Data
RefSeq NP_001025006
Locus ID 83605
UniProt ID Q9BSQ5
Cytogenetics 7p13
Synonyms CCM2, C7orf22, PP10187
Summary This gene encodes a scaffold protein that functions in the stress-activated p38 Mitogen-activated protein kinase (MAPK) signaling cascade. The protein interacts with SMAD specific E3 ubiquitin protein ligase 1 (also known as SMURF1) via a phosphotyrosine binding domain to promote RhoA degradation. The protein is required for normal cytoskeletal structure, cell-cell interactions, and lumen formation in endothelial cells. Mutations in this gene result in cerebral cavernous malformations. Multiple transcript variants encoding different isoforms have been found for this gene.provided by RefSeq, Nov 2009
Protein Categories Intracellular Proteins
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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