AADC / DDC (1-480, His-tag)

CAT#: AR09186PU-L

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Recombinant Human Dopa decarboxylase protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography.


 Product Datasheet for 'AR09186PU-L'

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USD 820.00


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2 Weeks

Size
    • 500 ug


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Product Data
Description Recombinant Human Dopa decarboxylase protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography.
Species Human
Expression Host E. coli
Tag His-tag
Predicted MW 56.4 kDa
Concentration 1 mg/ml (determined by Bradford assay)
Purity > 95 % by SDS - PAGE
Buffer 20 mM Tris-HCl buffer (pH 8.0) containing 2 mM DTT, 10% glycerol
Preparation Liquid purified protein
Reference Data
RefSeq NP_000781
Locus ID 1644
Cytogenetics 7p12.2-p12.1
Synonyms AADC
Summary The encoded protein catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine. Defects in this gene are the cause of aromatic L-amino-acid decarboxylase deficiency (AADCD). AADCD deficiency is an inborn error in neurotransmitter metabolism that leads to combined serotonin and catecholamine deficiency. Multiple alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jun 2011]
Protein Families Druggable Genome
Protein Pathways Histidine metabolism, Metabolic pathways, Phenylalanine metabolism, Tryptophan metabolism, Tyrosine metabolism

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68 Mouse Clones