IFNG / Interferon gamma Human Protein

CAT#: AR09041PU-N

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IFNG / Interferon gamma human recombinant protein, 0.1 mg



USD 260.00


Availability*
2 Weeks

Size
    • 100 ug


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Specifications

Product Data
Description IFNG / Interferon gamma human recombinant protein, 0.1 mg
Species Human
Expression Host E. coli
Expression cDNA Clone or AA Sequence MQDPYVKEAE NLKKYFNAGH SDVADNGTLF LGILKNWKEE SDRKIMQSQI VSFYFKLFKN FKDDQSIQKS VETIKEDMNV KFFNSNKKKR DDFEKLTNYS VTDLNVQRKA IHELIQVMAE LSPAAKTGKR KRSQMLFRGR RASQ
Predicted MW 16.9 kDa
Concentration 1.0 mg/ml (determined by Absorbance at 280nm)
Purity >95% pure by SDS-PAGE
Buffer Presentation State: Purified
State: Liquid purified protein
Buffer System: PBS, pH 7.4 containing 10% Glycerol
Bioactivity Biological: Measured in a cytotoxicity assay using WiDr cells. The ED50 for this effect is ≤ 5 ng/ml.
Endotoxin < 1.0 EU per 1 µg of Protein (determined by LAL method).
Preparation Liquid purified protein
Protein Description Recombinant Human interferon-γ was expressed in E.coli and purified by FPLC gel-filtration chromatography, after refolding of the isolated inclusion bodies in a renaturation buffer. Additional amino acid (Methionine) is attached at N-terminus.
Storage Store undiluted at 2-8°C for one month or (in aliquots) at -20°C to -80°C for longer.
Avoid repeated freezing and thawing.
Stability Shelf life: one year from despatch.
Reference Data
RefSeq NP_000610
Locus ID 3458
Cytogenetics 12q15
Synonyms IFG; IFI
Summary This gene encodes a soluble cytokine that is a member of the type II interferon class. The encoded protein is secreted by cells of both the innate and adaptive immune systems. The active protein is a homodimer that binds to the interferon gamma receptor which triggers a cellular response to viral and microbial infections. Mutations in this gene are associated with an increased susceptibility to viral, bacterial and parasitic infections and to several autoimmune diseases. [provided by RefSeq, Dec 2015]
Protein Families Druggable Genome, Secreted Protein
Protein Pathways Allograft rejection, Cytokine-cytokine receptor interaction, Graft-versus-host disease, Jak-STAT signaling pathway, Natural killer cell mediated cytotoxicity, Proteasome, Regulation of autophagy, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, Type I diabetes mellitus

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