PSMC3 Rabbit Polyclonal Antibody

CAT#: TA392857

PSMC3 (V306) polyclonal antibody

Product Images

Western blot (WB) analysis of PSMC3 (V306) pAb at 1:500 dilution Lane1:MCF-7 whole cell lysate(20ug) Lane2:HEK293T whole cell lysate(20ug) Lane3:The Uterus tissue lysate of Rat(20ug) Lane4:The Kidney tissue lysate of Mouse(40ug)

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  Immunohistochemistry (IHC) analyzes of PSMC3 (V306) pAb in paraffin-embedded human lung carcinoma tissue at 1:100.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB: 1:500~1:1000 IHC: 1:50~1:200
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide, corresponding to amino acids 180-230 of Human PSMC3.
• Specificity: PSMC3 (V306) polyclonal antibody detects endogenous levels of PSMC3 protein.
• Formulation: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
• Concentration: 1mg/ml
• Conjugation: Unconjugated
• Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
• Stability: 1 year
• Predicted Protein Size: ~ 49 kDa
• Gene Name: proteasome 26S subunit, ATPase 3
• Database Link:
  Entrez Gene 5702 Human
  UniProt ID P17980
• Background: The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases that have chaperone-like activity. This subunit may compete with PSMC2 for binding to the HIV tat protein to regulate the interaction between the viral protein and the transcription complex. A pseudogene has been identified on chromosome 9.
• Synonyms: 26S protease regulatory subunit 6A; 26S proteasome AAA-ATPase subunit RPT5; Human immunodeficiency virus tat transactivator binding protein 1; MGC8487; Proteasome (prosome macropain) 26S subunit ATPase 3; Proteasome 26S ATPase subunit 3; Proteasome 26S subunit ATPase 3; Proteasome subunit P50; PRS6A; PSMC 3; PSMC3; TAT-binding protein 1; Tat binding protein 1; TBP-1; TBP1
• Note: For research use only, not for use in diagnostic procedure.