NR2F2 Rabbit Polyclonal Antibody

CAT#: TA392525

COUP-TFI polyclonal antibody

Product Images

Western blot (WB) analysis of COUP-TFI polyclonal antibody at 1:10000 dilution Lane1:The Heart tissue lysate of Pig(40ug) Lane2:The Brain tissue lysate of Pig(40ug)

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB: 1:5000~1:10000
• Reactivities: Pig
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide, corresponding to Human COUP-TFI.
• Specificity: COUP-TFI polyclonal antibody detects endogenous levels of COUP-TFI protein.
• Formulation: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.
• Concentration: 1mg/ml
• Conjugation: Unconjugated
• Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
• Stability: 1 year
• Predicted Protein Size: ~ 52 kDa
• Gene Name: nuclear receptor subfamily 2 group F member 2
• Database Link:
  UniProt ID P24468
• Background: Chicken ovalbumin upstream promoter transcription factor (COUP-TF) belongs to the NR2 subfamily of the nuclear hormone receptor family. COUP-TFI and COUP-TFII are two of the well-characterized members in the NR2 subfamily. These two members are highly conserved in their two zinc-finger DNA binding domains (DBD) and the ligand binding domain (LBD), and function as repressors or activators of downstream target genes to regulate different biological processes. COUP-TFI and II bind to 5'-AGGTCA-3' motif palindromes, either directly or indirectly, through heterodimer formation with other proteins (e.g. RXRs) to regulate downstream target gene expression. COUP-TFI is involved in neuronal development, tissue patterning, and differentiation. COUP-TFII has been shown to be involved in angiogenesis, glucose homeostasis, and mesenchymal cell commitment.
• Synonyms: Apolipoprotein A-I regulatory protein 1; ARP-1; ARP1, TFCOUP2; COUP-TF2; COUP-TF II; COUP transcription factor 2; COUP transcription factor II; NR2F2; Nuclear receptor subfamily 2 group F member 2
• Note: For research use only, not for use in diagnostic procedure.