alpha smooth muscle Actin (ACTA2) Rabbit Polyclonal Antibody

CAT#: TA392476

α-SMA polyclonal antibody

Product Images

Western blot (WB) analysis of α-SMA pAb at 1:1000 dilution Lane1:MCF-7 whole cell lysate(40ug) Lane2:HepG2 whole cell lysate(40ug)

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB: 1:1000~1:2000
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide, corresponding to Human α-SMA.
• Specificity: α-SMA polyclonal antibody detects endogenous levels of α-SMA protein.
• Formulation: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
• Concentration: 1mg/ml
• Conjugation: Unconjugated
• Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
• Stability: 1 year
• Predicted Protein Size: ~ 45 kDa
• Gene Name: actin, alpha 2, smooth muscle, aorta
• Database Link:
  Entrez Gene 59 Human
  UniProt ID P62736
• Background: Defects in ACTA2 are the cause of aortic aneurysm familial thoracic type 6 (AAT6) [MIM:611788]. AATs are characterized by permanent dilation of the thoracic aorta usually due to degenerative changes in the aortic wall. They are primarily associated with a characteristic histologic appearance known as 'medial necrosis' or 'Erdheim cystic medial necrosis' in which there is degeneration and fragmentation of elastic fibers, loss of smooth muscle cells, and an accumulation of basophilic ground substance.
• Synonyms: a-SMA; AAT6; ACTA2; Actin, aortic smooth muscle; ACTSA; Alpha-actin-2; alpha-SMA; aSMA; Cell growth-inhibiting gene 46 protein; MYMY5; SMA-alpha
• Note: For research use only, not for use in diagnostic procedure.