SH2D1A Rabbit Monoclonal Antibody [Clone ID: R09-5F6]

CAT#: TA385238

SH2D1A Rabbit monoclonal Antibody

Product Images

Western blot analysis of SH2D1A/SAP in 3T3 lysates using SH2D1A antibody.

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  Western blot analysis of SH2D1A/SAP in MCF-7, C6 lysates using SH2D1A/SAP antibody.

Specifications

Product Data

• Clone Name: R09-5F6
• Applications: WB
• Recommended Dilution: WB: 1/1000-1/2000
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Monoclonal
• Immunogen: A synthetic peptide of human SH2D1A/SAP
• Formulation: 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
• Concentration: lot specific
• Purification: Affinity Purified
• Conjugation: Unconjugated
• Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
• Stability: 1 year
• Predicted Protein Size: Calculated MW: 14 kDa; Observed MW: 14 kDa
• Gene Name: SH2 domain containing 1A
• Database Link:
  Entrez Gene 4068 Human
  UniProt ID O60880
• Background: Swiss-Prot Acc.O60880.Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family such as SLAMF1, CD244, LY9, CD84, SLAMF6 and SLAMF7. In SLAM signaling seems to cooperate with SH2D1B/EAT-2. Initially it has been proposed that association with SLAMF1 prevents SLAMF1 binding to inhibitory effectors including INPP5D/SHIP1 and PTPN11/SHP-2 (PubMed:11806999). However, by simultaneous interactions, recruits FYN which subsequently phosphorylates and activates SLAMF1 (PubMed:12458214). Positively regulates CD244/2B4- and CD84-mediated natural killer (NK) cell functions. Can also promote CD48-, SLAMF6 -, LY9-, and SLAMF7-mediated NK cell activation. In the context of NK cell-mediated cytotoxicity enhances conjugate formation with target cells . May also regulate the activity of the neurotrophin receptors NTRK1, NTRK2 and NTRK3.
• Synonyms: DSHP; EBVS; FLJ18687; FLJ92177; IMD5; LYP; MTCP1; SAP; XLP; XLPD