Phospholipase A2 IIA (PLA2G2A) Rabbit Monoclonal Antibody [Clone ID: R09-4F9]

CAT#: TA384991

Secretory Phospholipase A2 Rabbit monoclonal Antibody

Product Images

Western blot analysis of Secretory Phospho-lipase A2 in K562, C6, 3T3, Hela lysates using Secretory Phospho-lipase A2 antibody.

Specifications

Product Data

• Clone Name: R09-4F9
• Applications: WB
• Recommended Dilution: WB: 1/1000
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Monoclonal
• Immunogen: A synthetic peptide of human Secretory phospholipase A2
• Formulation: 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
• Concentration: lot specific
• Purification: Affinity Purified
• Conjugation: Unconjugated
• Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
• Stability: 1 year
• Predicted Protein Size: Calculated MW: 16 kDa; Observed MW: 16 kDa
• Gene Name: phospholipase A2 group IIA
• Database Link:
  Entrez Gene 5320 Human
  UniProt ID P14555
• Background: Swiss-Prot Acc.P14555.Catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides (PubMed:2925633). Thought to participate in the regulation of phospholipid metabolism in biomembranes including eicosanoid biosynthesis. Independent of its catalytic activity, acts as a ligand for integrins (PubMed:18635536, PubMed:25398877). Binds to and activates integrins ITGAV:ITGB3, ITGA4:ITGB1 and ITGA5:ITGB1 (PubMed:18635536, PubMed:25398877). Binds to a site (site 2) which is distinct from the classical ligand-binding site (site 1) and induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed:25398877). Induces cell proliferation in an integrin-dependent manner (PubMed:18635536).
• Synonyms: MOM1; NPS-PLA2; PLA2; PLA2B; PLA2L; PLA2S; PLAS1; RASF-A; sPLA2