LC3B (MAP1LC3B) Mouse Monoclonal Antibody [Clone ID: 8H6-6D10-3A4]

CAT#: TA384700

LC3B (8H6) Mouse monoclonal Antibody

Product Images

Immunohistochemistry analysis of paraffin-embedded Human Brain Tissue using LC3B (8H6) antibody.High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.

Specifications

Product Data

• Clone Name: 8H6-6D10-3A4
• Applications: IHC
• Recommended Dilution: IHC: 1/100-200
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Purified recombinant protein expressed in E.coli.
• Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.03% Proclin 300, pH 7.3.
• Concentration: lot specific
• Purification: Affinity Purified
• Conjugation: Unconjugated
• Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
• Stability: 1 year
• Predicted Protein Size: 14,16kDa
• Gene Name: microtubule associated protein 1 light chain 3 beta
• Database Link:
  Entrez Gene 81631 Human
  UniProt ID Q9GZQ8
• Background: Swiss-Prot Acc.Q9GZQ8.Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes). Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation. Promotes primary ciliogenesis by removing OFD1 from centriolar satellites via the autophagic pathway.
• Synonyms: LC3B; MAP1A/1BLC3; MAP1ALC3