KCTD21 Rabbit Monoclonal Antibody [Clone ID: R02-4B5]

CAT#: TA384589

KCTD21 Rabbit monoclonal Antibody

Product Images

Western blot analysis of KCTD21 in mouse brain, rat brain lysates using KCTD21 antibody.

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  Western blot analysis of KCTD21 in K562 lysates using KCTD21 antibody.

Specifications

Product Data

• Clone Name: R02-4B5
• Applications: WB
• Recommended Dilution: WB: 1/1000
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Monoclonal
• Immunogen: Recombinant protein of human KCTD21
• Formulation: 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
• Concentration: lot specific
• Purification: Affinity Purified
• Conjugation: Unconjugated
• Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
• Stability: 1 year
• Predicted Protein Size: Calculated MW: 30 kDa; Observed MW: 30 kDa
• Gene Name: potassium channel tetramerization domain containing 21
• Database Link:
  Entrez Gene 283219 Human
  UniProt ID Q4G0X4
• Background: Swiss-Prot Acc.Q4G0X4.Probable substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex mediating the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes the ubiquitination of HDAC1. Can function as antagonist of the Hedgehog pathway by affecting the nuclear transfer of transcription factor GLI1; the function probably occurs via HDAC1 down-regulation, keeping GLI1 acetylated and inactive. Inhibits cell growth and tumorigenicity of medulloblastoma (MDB) (PubMed:21472142).
• Synonyms: Kctd21