H2BC19P Rabbit Monoclonal Antibody [Clone ID: R07-8K4]

CAT#: TA384369

Histone H2B Rabbit monoclonal Antibody

Product Images

Western blot analysis of Histone H2B Receptor in 3T3 lysates using Histone H2B antibody.

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  Western blot analysis of Histone H2B in K562, C6 lysates using Histone H2B antibody.

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  Immunohistochemistry analysis of paraffin-embedded Human colon cancer using Histone H2B antibody. High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.

Specifications

Product Data

• Clone Name: R07-8K4
• Applications: IHC, IP, WB
• Recommended Dilution: WB: 1/2000
  IHC: 1/200
  IP: 1/20
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Monoclonal
• Immunogen: A synthetic peptide of human Histone H2B
• Formulation: 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
• Concentration: lot specific
• Purification: Affinity Purified
• Conjugation: Unconjugated
• Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
• Stability: 1 year
• Predicted Protein Size: Calculated MW: 14 kDa; Observed MW: 14 kDa
• Gene Name: histone cluster 2, H2bd (pseudogene)
• Database Link:
  Entrez Gene 337874 Human
  UniProt ID O60814
• Background: Swiss-Prot Acc.O60814.Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid.
• Synonyms: HIST2H2BD