GAP43 Rabbit Polyclonal Antibody

CAT#: SP1375P

GAP43 rabbit polyclonal antibody, Serum

Specifications

Product Data

• Applications: IHC, IP, WB
• Recommended Dilution: Immunoprecipitation.
  Immunohistochemistry on frozen sections.
  Western Blot: 1/500 - 1/1000.
• Reactivities: Mammalian
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Purified rat GAP-43
• Specificity: This antibody recognises the protein designated GAP-43.
• Formulation: Containing 0.09% Sodium Azide
  State: Serum
  State: Liquid serum
• Conjugation: Unconjugated
• Storage: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: growth associated protein 43
• Database Link:
  UniProt ID P17677
• Background: GAP-43 is a neuronal protein that is expressed at elevated levels during development and also during regenerative axon growth. GAP-43 (also known as neuromodulin, pp46, B-50, Protein F1 and calmodulin-binding protein P-57) is a protein of approximately 25kD that migrates on SDS-PAGE gels with an apparent size of 40-50kD. The aberrant migration is due to the unusually low abundance of hydrophobic amino acid residues. GAP43 is found tightly associated with neuronal membranes due to palmitoylation. The solubilised protein binds calmodulin, although this is reduced following protein kinase C phosphorylation of GAP-43.
• Synonyms: Neuromodulin