DR4 (TNFRSF10A) Mouse Monoclonal Antibody [Clone ID: DR-4-02]

CAT#: SM3131AC

DR4 (TNFRSF10A) mouse monoclonal antibody, clone DR-4-02, APC

Product Images

Immunofluorescence staining (confocal microscopy) of HeLa human cervix carcinoma cell line transfected with TRAIL-R1 expression plasmid using anti-human TRAIL-R1 (DR-4-02).

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  Surface staining of partially CD261-transfected HEK-293 cells with anti-CD261/TRAIL-R1 (DR-4-02) APC.

Specifications

Product Data

• Clone Name: DR-4-02
• Applications: FC, IF
• Recommended Dilution: Flow cytometry.
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Fusion protein containing the extracellular part of TRAIL-R1 and the constant part of the heavy chain of the human IgG1
• Specificity: This antibody recognizes TRAIL-R1 (DR4), a human death receptor 4 (468 amino acids) expressed in most human tissues (spleen, peripheral blood leucocytes, thymus) and in a variety of tumour-derived cell lines.
• Formulation: Phosphate buffered saline (PBS)
  Label: APC
  State: Liquid purified Ig fraction
  Stabilizer: 0.2% (w/v) high-grade protease free BSA
  Preservative: 15 mM Sodium Azide
  Label: Conjugated with cross-linked Allophycocyanin (APC) under optimum conditions.
  The conjugate is purified by size-exclusion chromatography.
• Concentration: lot specific
• Purification: The conjugate is purified by size-exclusion chromatography
• Conjugation: APC
• Storage: Store the antibody undiluted at 2-8°C.
  DO NOT FREEZE!
  This product is photosensitive and should be protected from light.
• Stability: Shelf life: one year from despatch.
• Gene Name: tumor necrosis factor receptor superfamily member 10a
• Database Link:
  Entrez Gene 8797 Human
  UniProt ID O00220
• Background: TRAIL-R1 (CD261, DR4) is a type I transmembrane protein, also called TRAIL receptor 1. The ligand for this DR4 death receptor has been identified and termed TRAIL, which is a member of the TNF family. DR4, as many other receptors (Fas, TNFR1, etc.), mediates apoptosis and NF kappaB activation in many cells and tissues. Apoptosis, a programmed cell death, is a operating process in normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by coupled of certain cytokines (TNF family - TNF, Fas ligand) and their death domain containing receptors (TNFR1, Fas receptor).
• Synonyms: APO2, DR4, Death receptor 4, TRAIL receptor 1, TRAIL-R1, TNFRSF10A