CD59 Mouse Monoclonal Antibody [Clone ID: MEM-129]

CAT#: SM3101A

CD59 mouse monoclonal antibody, clone MEM-129, Azide Free

Specifications

Product Data

• Clone Name: MEM-129
• Applications: FC, FN
• Recommended Dilution: Flow Cytometry: 2-8 µg/ml.
  Functional Studies: The antibody activates T-cells.
• Reactivities: Human, Porcine
• Host: Mouse
• Isotype: IgM
• Clonality: Monoclonal
• Immunogen: Human peripheral blood lymphocytes
• Specificity: The antibody MEM-129 reacts with CD59 (Protectin).
• Formulation: Azide free HEPES buffered saline (HBS), approx. pH 7.0; 0.2 um filter sterilized
  State: Azide Free
  State: Liquid purified Ig fraction (> 95% pure by SDS-PAGE)
• Concentration: lot specific
• Purification: Thiophilic Adsorption-Affinity Chromatography and Size-Exclusion Chromatography
• Conjugation: Unconjugated
• Storage: Store the antibody undiluted at 2-8°C.
  DO NOT FREEZE!
  Should this product contain a precipitate we recommend microcentrifugation before use.
• Stability: Shelf life: one year from despatch.
• Gene Name: CD59 molecule
• Database Link:
  Entrez Gene 966 Human
  UniProt ID P13987
• Background: CD59 (Protectin) is a small (18-20 kDa) GPI-anchored ubiquitously expressed inhibitor of the membrane attack complex (MAC). It is thus the key regulator that preserves the autologous cells from terminal effector mechanism of the complement cascade. CD59 associates with C5b-8 complex and thereby counteracts appropriate formation of cytolytic pore within the plasma membrane. CD59 is also an low-affinity ligand of human CD2 and causes T cell costimulation.
• Synonyms: MAC-inhibitory protein, Protectin, MEM43 antigen, MIC11, MIN1, MIN2, MIN3, MSK21, MACIF, MAC-IP, MIRL, HRF20, HRF-20