CD41 (ITGA2B) Mouse Monoclonal Antibody [Clone ID: MEM-06]

CAT#: SM3021PP

CD41 (ITGA2B) mouse monoclonal antibody, clone MEM-06, PerCP

Product Images

Surface staining of human platelets with anti-human CD41 PE (SM3021R).

Specifications

Product Data

• Clone Name: MEM-06
• Applications: FC
• Recommended Dilution: Flow Cytometry analysis of human blood cells using 10 ?l reagent / 100 ?l of whole blood or 10⁶ cells in a suspension.
  The content of a vial (1 ml) is sufficient for 100 tests.
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Leukocytes of patient suffering from LGL-type leukaemia
• Specificity: This antibody reacts with CD41 (GPIIb), a transmembrane glycoprotein (integrin family) composed of two chains GPIIb alpha (heavy chain; 120 kDa) and GPIIb beta (light chain; 23 kDa). CD41 is mainly expressed on platelets and megakaryocytes.
• Formulation: Phosphate buffered saline (PBS)
  Label: PerCP
  State: Liquid purified Ig fraction
  Preservative: 15 mM sodium azide
  Label: Conjugated with Peridinin-chlorophyll-protein complex (PerCP) under optimum conditions. The conjugate is purified by size-exclusion chromatography and adjusted for direct use.
• Conjugation: PerCP
• Storage: Store undiluted at 2-8°C. DO NOT FREEZE! This products is photosensitive and should be protected from light.
• Stability: Shelf life: one year from despatch.
• Gene Name: integrin subunit alpha 2b
• Database Link:
  Entrez Gene 3674 Human
  UniProt ID P08514
• Background: CD41 (platelet glycoprotein IIb) is composed of two subunits (120 kDa a, alpha and 23 kDa b, beta) that interact with CD61 in the presence of calcium to form a functional adhesive protein receptor. Upon blood vessel damage, this receptor binds to a variety of proteins including von Willebrand factor, fibrinogen, fibronectin and vitronectin. CD41 is mainly expressed on megakaryocyte-platelet lineage, but generally belongs to the antigens that are expressed during early stages of hematopoietic differentiation.
• Synonyms: Integrin alpha-IIb, GP2B, ITGAB, GPalpha IIb