CD71 / TFRC Mouse Monoclonal Antibody [Clone ID: OX-26]

CAT#: SM289R

CD71 / TFRC mouse monoclonal antibody, clone OX-26, PE

Product Images

Staining of rat spleen cells with MOUSE ANTI RAT CD71:RPE (SM289R).

Specifications

Product Data

• Clone Name: OX-26
• Applications: FC
• Recommended Dilution: Flow cytometry.
• Reactivities: Rat
• Host: Mouse
• Isotype: IgG2a
• Clonality: Monoclonal
• Immunogen: PHA activated rat lymphocytes. Spleen cells from immunised Balb/c mice were fused with cells of the NS1 mouse myeloma cell line.
• Specificity: This antibody recognises CD71, also known as transferrin receptor. Clone MRC OX-26 also binds to a number of non-dividing normal tissues. The balance between a sufficient amount of iron uptake and prevention of accumulation of excess iron within a cell, is vitally important to maintain cellular functions such as oxygen and electron transport and mitochondrial energy metabolism, whilst preventing permanent cell and tissue damage. Clone MRC OX-26 is reported as suitable for use in Electron Microscopy.
• Formulation: PBS, pH7.4 containing 0.09% Sodium Azide and 1% Bovine Serum Albumin
  Label: PE
  State: Lyophilized purified IgG
  Label: R. Phycoerythrin (RPE)
• Reconstitution Method: Restore with 1 ml distilled water
• Purification: Affinity chromatography on protein G
• Conjugation: PE
• Storage: Prior to and following reconstitution store the antibody at 2-8°C.
  DO NOT FREEZE!
  This product is photosensitive and should be protected from light.
• Stability: Shelf life: one year from despatch.
• Database Link:
  UniProt ID Q99376
• Background: CD71 is a homodimeric type II transmembrane protein, expressed by all proliferating cells and cells with a requirement for iron, including reticulocytes and capillary endothelium in brain. Transferrin receptor (CD71), transferrin and ferritin have been identified as specialised proteins which control the uptake, transport and storage of free iron in tissues, thereby maintaining iron homeostasis. An imbalance in iron homeostasis within the brain has been linked with the neurodegenerative diseases, Alzheimers, Parkinsons, Huntingtons and Multiple Sclerosis.
• Synonyms: TfR1, p90, Transferrin receptor protein 1