Clec7a Rat Monoclonal Antibody [Clone ID: 2A11]

CAT#: SM2052FS

Clec7a rat monoclonal antibody, clone 2A11, FITC

Product Images

Staining of mouse peripheral blood granulocytes with Rat Anti Mouse Beta Glucan Receptor:FITC.

Specifications

Product Data

• Clone Name: 2A11
• Applications: FC
• Recommended Dilution: Flow Cytometry.
• Reactivities: Mouse
• Host: Rat
• Isotype: IgG2b
• Clonality: Monoclonal
• Immunogen: Dectin-1 transfected NIH3T3 cells and recombinant soluble Dectin-1.
• Specificity: Recognises Murine beta-Glucan Receptor (Dectin-1).
  Dectin-1 is predominantly expressed by cells of the monocyte/macrophage and neutrophil lineages, but also at lower levels by dendritic cells and a subpopulation of T cells.
  This antibody inhibits the binding of zymosan to macrophages via the beta-glucan receptor. The low endotoxin version SM2025LE is recommended for Functional Studies.
• Formulation: PBS, pH 7.4 containing 0.09% Sodium Azide as preservative and 1% BSA as stabilizer.
  Label: FITC
  State: Liquid purified IgG fraction.
  Label: Fluorescein Isothiocyanate Isomer 1
• Concentration: lot specific
• Purification: Affinity Chromatography on Protein G.
• Conjugation: FITC
• Storage: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  This product is photosensitive and should be protected from light.
  Should this product contain a precipitate we recommend microcentrifugation before use.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: C-type lectin domain family 7, member a
• Database Link:
  Entrez Gene 56644 Mouse
  UniProt ID Q6QLQ4
• Background: As a major leucocyte receptor for beta-glucan this molecule may have a key role in the immunomodulatory effects of beta-glucans and in the host response to fungal pathogens.
  Recent work has shown that Dectin-1 may stimulate reactive oxygen production in macropahges via the protein tyrosine kinase known as Syk.
• Synonyms: Beta-glucan receptor, BGR, CLECSF12, DECTIN1