B7-1 (CD80) Mouse Monoclonal Antibody [Clone ID: MEM-233]

CAT#: SM1742PP

B7-1 (CD80) mouse monoclonal antibody, clone MEM-233, PerCP

Specifications

Product Data

• Clone Name: MEM-233
• Applications: FC
• Recommended Dilution: Flow Cytometry analysis of human blood cells using 10 μl reagent / 100 μl of whole blood or 10⁶ cells in a suspension.
  The content of a vial (1 ml) is sufficient for 100 tests.
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Extracellular domain of human CD80 fused to human IgG1(Fc)
• Specificity: This antibody reacts with CD80 (B7-1), a 60 kDa single chain type I glycoprotein of immunoglobulin supergene family, expressed on professional antigen-presenting cells, such as dendritic cells, macrophages or activated B lymphocytes.
• Formulation: Phosphate buffered saline (PBS)
  Label: PerCP
  State: Liquid purified Ig fraction
  Preservative: 15 mM sodium azide
  Label: Conjugated with Peridinin-chlorophyll-protein complex (PerCP) under optimum conditions. The conjugate is purified by size-exclusion chromatography and adjusted for direct use.
• Conjugation: PerCP
• Storage: Store undiluted at 2-8°C. DO NOT FREEZE! This products is photosensitive and should be protected from light.
• Stability: Shelf life: one year from despatch.
• Gene Name: CD80 molecule
• Database Link:
  Entrez Gene 941 Human
  UniProt ID P33681
• Background: CD80 (B7-1) and CD86 (B7-2) are ligands of T cell critical costimulatory molecule CD28 and of an inhibitory receptor CTLA-4 (CD152). The both B7 molecules are expressed on professional antigen-presenting cells and are essential for T cell activation, the both molecules can also substitute for each other in this process. The question what are the differences in CD80 and CD86 competency has not been fully elucidated yet; there are still conflicts in results about their respective roles in initiation or sustaining of the T cell immune response.
• Synonyms: CD28LG, CD28LG1, LAB7, BB1, B7.1, B7-1