LRP1 Mouse Monoclonal Antibody [Clone ID: alpha2MRalpha2]

CAT#: SM1729R

LRP1 mouse monoclonal antibody, clone alpha2MRalpha2, PE

Specifications

Product Data

• Clone Name: alpha2MRalpha2
• Applications: FC
• Recommended Dilution: Flow Cytometry: Use 10 µl of neat antibody to label 10⁶ cells in 100 µl.
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Purified alpha2 macroglobulin receptor.
  Spleen cells from immunised Balb/c mice were fused with cells of the NS1 mouse myeloma cell line.
• Specificity: This antibody, clone A2Mr alpha-2 recognizes Human CD91 a type I membrane protein which is also known as the alpha 2 macroglobulin receptor (alpha 2MR). This antibody recognizes an epitope in the extracellular region of the 500kD alpha chain.
• Formulation: PBS, pH 7.4
  Label: PE
  State: Lyophilized purified IgG fraction
  Stabilizer: 1% BSA, 5% Sucrose
  Preservative: 0.09% Sodium Azide
  Label: R. Phycoerythrin (RPE)
• Reconstitution Method: Restore with 1.0 ml distilled water
• Purification: Affinity Chromatography on Protein G
• Conjugation: PE
• Storage: Prior to and following reconstitution store at 2-8°C.
  DO NOT FREEZE!
  This product is photosensitive and should be protected from light.
• Stability: Shelf life: one year from despatch.
• Gene Name: LDL receptor related protein 1
• Database Link:
  Entrez Gene 4035 Human
  UniProt ID Q07954
• Background: Low density lipoprotein receptor-related protein (also known as low density LRP, LRP1, alpha-2-macroglobulin receptor or Apolipoprotein E receptor) is an endocytotic receptor that is involved both in endocytosis and in phagocytosis of apoptotic cells. It is required for early embryonic development, is involved in cellular lipid homeostasis, and may play a role in APP metabolism, kinase-dependent intracellular signalling, neuronal calcium signalling and neurotransmission. Low density LRP also plays a role in the plasma clearance of chylomicron remnants and activated LRPAP1 (alpha-2-macroglobulin), and is involved in the local metabolism of complexes of plasminogen activators and their endogenous ligands. Low density LPR is postulated to be one of the major players in host resistance to HIV. The precursor low density LRP molecule is cleaved post-translationally to form a 85 kDa membrane-spanning subunit (LRP-85) and a 515 kDa large extracellular domain (LRP-515), which remains non-covalently associated with LRP-85. Following cleavage, the intracellular domain (LPRICD) is present in both the cytoplasm and the nucleus.
• Synonyms: A2MR, APR, APOER