IL3RA Mouse Monoclonal Antibody [Clone ID: 6H6]

CAT#: SM1190AC

IL3RA mouse monoclonal antibody, clone 6H6, APC

Product Images

Surface staining of human peripheral blood with anti-CD123 (6H6) APC.

Specifications

Product Data

• Clone Name: 6H6
• Applications: FC
• Recommended Dilution: Flow Cytometry analysis of human blood cells using 10 μl reagent / 100 μl of whole blood or 10⁶ cells in a suspension. The content of a vial (1 ml) is sufficient for 100 tests.
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: IL3 receptor alpha chain expressed on the surface of transiently transfected COS cells
• Specificity: This antibody recognizes CD123 (interleukin 3 receptor alpha), a 60-70 kDa transmembrane protein expressed by myeloid precursors, megakaryocytes, macrophages, dendritic cells, mast cells, basophils, and some B cells. This antibody does not inhibit IL-3 binding to its receptor.
• Formulation: PBS
  Label: APC
  State: Liquid Ig fraction
  Stabilizer: 0.2% (w/v) high-grade protease free BSA
  Preservative: 15 mM Sodium Azide
  Label: Conjugated with cross-linked Allophycocyanin (APC) under optimum conditions.
• Purification: Size-Exclusion Chromatography
• Conjugation: APC
• Storage: Store the antibody undiluted at 2-8°C.
  DO NOT FREEZE!
  This product is photosensitive and should be protected from light.
• Stability: Shelf life: one year from despatch.
• Gene Name: interleukin 3 receptor subunit alpha
• Database Link:
  Entrez Gene 3563 Human
  UniProt ID P26951
• Background: CD123 is the alpha chain of interleukin 3 receptor (IL-3R alpha). This subunit heterodimerizes with the interleukin 3 receptor beta chain (CD131), which is shared with other receptors. CD123 interacts with IL-3 specifically, but with low affinity, and association with the beta subunit confers high affinity binding to the receptor heterodimer. Both chains are required for signaling, but receptor activation and signal transduction depend on IL-3 binding to CD123 as the initial step.
• Synonyms: Interleukin-3 receptor subunit alpha, IL-3R-alpha, IL3 receptor alpha