C5R1 (C5AR1) (N-term) Mouse Monoclonal Antibody [Clone ID: S5/1]

CAT#: SM1182R

C5R1 (C5AR1) (N-term) mouse monoclonal antibody, clone S5/1, PE

Product Images

Surface staining of human peripheral blood using anti-CD88 (clone S5/1) PE.

Specifications

Product Data

• Clone Name: S5/1
• Applications: FC
• Recommended Dilution: Flow Cytometry analysis of human blood cells using 10 μl reagent / 100 μl of whole blood or 10⁶ cells in a suspension.
  The content of a vial (1 ml) is sufficient for 100 tests.
• Reactivities: Human, Bovine, Rabbit, Ferret
• Host: Mouse
• Isotype: IgG2a
• Clonality: Monoclonal
• Immunogen: Recombinant N-terminal peptide (Asp15-Asp27) of human C5aR
• Specificity: This antibody recognizes the CD88 protein, a 43 kDa receptor of C5a component of the complement cascade.
• Formulation: Phosphate buffered saline (PBS)
  Label: PE
  State: Liquid purified Ig fraction
  Preservative: 15 mM sodium azide
  Label: Conjugated with R-Phycoerythrin (PE) under optimum conditions. The conjugate is purified by size-exclusion chromatography and adjusted for direct use.
• Conjugation: PE
• Storage: Store the antibody undiluted at 2-8°C.
  DO NOT FREEZE!
  This product is photosensitive and should be protected from light.
• Stability: Shelf life: one year from despatch.
• Gene Name: complement component 5a receptor 1
• Database Link:
  Entrez Gene 728 Human
  UniProt ID P21730
• Background: CD88 / C5aR is a G protein-coupled seven membrane-spanning protein serving as a receptor for C5a component of the complement cascade, and is expressed mainly by monocytes, macrophages, neutrophils, eosinophils, and mast cells, but also e.g. by hepatocytes, glial cells, vascular endothelial cells, or cardiomyocytes. The binding of C5a to CD88 is associated with inflammatory response, including superoxide anion production, chemotaxis, and increased production of acute phase proteins. Expression of CD88 on synovial mast cells and their C5a-mediated degranulation plays a role in pathogenesis of rheumatoid arthritis.
• Synonyms: C5a-R, C5aR, C5AR1, Complement Component 5a Receptor 1