CD42a (GP9) Mouse Monoclonal Antibody [Clone ID: GRP-P]

CAT#: SM1104R

CD42a (GP9) mouse monoclonal antibody, clone GRP-P, PE

Product Images

Staining of human peripheral blood platelets with MOUSE ANTI HUMAN CD42a:RPE

Specifications

Product Data

• Clone Name: GRP-P
• Applications: FC
• Recommended Dilution: Flow Cytometry.
• Reactivities: Canine, Human, Mink
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Human red blood cells and platelets.
  Spleen cells from immunised BALB/c mice were fused with cells of the mouse NS1 myeloma cell line.
• Specificity: The mouse monoclonal antibody GR-P (also known as GRP-P) recognizes CD42a (glycoprotein 9), a 22 kDa transmembrane protein constitutively expressed on megakaryocytes and platelets. HLDA IV.; WS Code P 35.
• Formulation: PBS, pH~7.4
  Label: PE
  State: Lyophilized purified IgG fraction
  Stabilizer: 1% BSA, 5% Sucrose
  Preservative: 0.09% Sodium Azide
  Label: R. Phycoerythrin (RPE)
• Reconstitution Method: Restore with 1 ml distilled water
• Purification: Ion Exchange Chromatography
• Conjugation: PE
• Storage: Prior to and following reconstitution store the antibody at 2-8°C.
  DO NOT FREEZE!
  This product is photosensitive and should be protected from light.
• Stability: Shelf life: one year from despatch.
• Gene Name: glycoprotein IX platelet
• Database Link:
  Entrez Gene 2815 Human
  UniProt ID P14770
• Background: CD42a, also known as Glycoprotein 9 (GPIX), composes together with GPIb alpha, GPIb beta and GPV the GPIb-IX-V receptor complex critical in the process of platelet-rich thrombus formation by tethering the platelet to a thrombogenic surface. CD42b binds to von Willebrand factor (VWF) exposed at a site of vascular injury, as well as to thrombin, coagulation factors XI and XII, high molecular wight kininogen, TSP-1, integrin Mac-1 and Pselectin. Defects in the gene encoding CD42a are a cause of Bernard-Soulier syndrome, also known as giant platelet disease. These patients have unusually large platelets and have a clinical bleeding tendency.
• Synonyms: Platelet glycoprotein IX, GP-IX, GP9