Fetuin A (AHSG) Rabbit Polyclonal Antibody
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Specifications
Product Data | |
Applications | ELISA, IHC, WB |
Recommended Dilution | ELISA. Western Blot. Immunohistochemistry on frozen sections. |
Reactivities | Human |
Host | Rabbit |
Clonality | Polyclonal |
Immunogen | Human serum |
Specificity | This antibody reacts to Fetuin-A. |
Formulation | 0.05 M phosphate buffer, 0.1 M NaCl, pH 7.2. AZIDE FREE State: Aff - Purified State: Lyophilized purified IgG |
Reconstitution Method | Restore with 0.1 ml of deionized water |
Concentration | lot specific |
Purification | Immunoaffinity chromatography |
Conjugation | Unconjugated |
Storage | Store lyophilized (preferably in a desiccator) at -20°C and in aliquots at -80°C. Reconstituted antibody can be stored at 4°C for a limited period of time; it does not show decline in activity after two weeks at 4°C. Avoid repeated freezing and thawing. |
Stability | Shelf life: one year from despatch. |
Gene Name | alpha 2-HS glycoprotein |
Database Link | |
Background | Fetuin-A (AHSG), a 59 kDa glycoprotein, consisting of two cystatin-like domains and a smaller unrelated domain, is predominantly sinthetized in liver . It is secreted into the blood stream and deposited as a noncollagenous protein in mineralized bones and teeth. Fetuin-A occurs in high serum concentrations during foetal life, whereas its level declines following infection, inflamatory and malignancy. Fetuin-A acts as an important circulating inhibitor of ectopic calcification, frequent complication of many degenerative diseases. Low serum level of Fetuin-A is associated with vascular and valvular calcification, atherosclerosis, malnutrition and higher cardiovascular mortality in chronic renal failure, liver cancer and liver cirrhosis patients on long-term dialysis. AHSG protein represents a natural inhibitor of tyrosinase kinase activity of the insulin receptor. It may play a significant role in regulating postprandial glucose disposal, insulin sensitivity, weight gain, and fat accumulation. The serum and bone-resident Fetuin-A binds to transforming growth factor- beta and blocks TGFbeta binding to cell surface receptors. |
Synonyms | Fetuin A, AHSG, FETUA, PRO2743 |
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