Ptgs2 Rabbit Polyclonal Antibody

CAT#: DP111-05

Ptgs2 rabbit polyclonal antibody, Purified

Product Images

Formalin fixed paraffin embedded human colon carcinoma stained with COX2 antibody. DP111

Specifications

Product Data

• Applications: IHC
• Recommended Dilution: Immunohistochemistry on paraffin embedded sections: 1:50-1:100 in an ABC method (30 minutes at room temperature).
  High temperature antigen retrieval with 10 mM citrate buffer, pH 6.0 required.
  Recommended Positive Control: Lung and colon carcinoma.
• Reactivities: Mouse, Rat
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Recombinant protein corresponding to c-terminus of rat COX2.
• Specificity: This antibody reacts with a 70 kD protein.
  Cellular Localization: Cytoplasmic, membrane
• Formulation: 10 mM citrate buffer, pH 6.0 containing sodium azide as preservative.
  State: Purified
  State: Liquid purified Ig fraction.
• Conjugation: Unconjugated
• Storage: Store the antibody undiluted at 2-8°C.
• Stability: Shelf life: one year from despatch.
• Gene Name: prostaglandin-endoperoxide synthase 2
• Database Link:
  Entrez Gene 19225 Mouse
  UniProt ID Q05769
• Background: COX2 (Cyclooxygenase-2) is an inducible enzyme. It is involved in the response of cells to growth factors, tumor promoters and cytokines that induce its expression. COX2 expression markedly increased in 85-90% of human colorectal adenocarcinoma whereas COX1 levels remain unchanged.
• Synonyms: Cyclooxygenase-2, PTGS2, COX2, PHS II, PGH synthase 2, PGHS-2, PGHS2