Herpes Virus Type 8 / HHV8 Rat Monoclonal Antibody [Clone ID: LN53]

CAT#: DM395-05

Herpes Virus Type 8 / HHV8 rat monoclonal antibody, clone LN53, Purified

Product Images

Cultured cells infected with HHV8 stained with HHV8 antibody DM395 /DM395-05 (Clone LN53).

Specifications

Product Data

• Clone Name: LN53
• Applications: IHC
• Recommended Dilution: Immunohistochemistry: Use at 1/25-1/50 dilution in an ABC method (30 to 60 minutes at room temperature).
  Formalin fixed paraffin embedded tissue sections require high temperature antigen unmasking with 10 mM citrate buffer, pH 6.0 prior to immunostaining.
  Recommended Positive Control: Kaposi's sarcoma.
• Reactivities: Human
• Host: Rat
• Isotype: IgG2c
• Clonality: Monoclonal
• Immunogen: Recombinant protein corresponding to the latent nuclear antigen-1 molecule of HHV8.
• Specificity: This antibody stains with ORF-73 of Human Herpesvirus 8 (HHV8). HHV8 is the likely etiological agent of Kaposi's sarcoma (KS). HHV8 encodes a latent nuclear antigen (LNA), which is the product of the viral gene orf 73. LNA is capable of forming a complex with retinoblastoma susceptibility gene product, which may be related to its oncogenic activity.
  Cellular Localization: Nuclear.
• Formulation: State: Purified
  State: Liquid purified Tissue Culture Supernatant
  Preservative: 0.09% Sodium Azide
• Conjugation: Unconjugated
• Storage: Store the antibody undiluted at 2-8°C.
• Stability: Shelf life: one year from despatch.
• Background: HHV8 has been found to be associated with three different diseases observed in AIDS patients; kaposi's sarcoma, primary effusion lymphoma (which is a rare type of non-Hodgkin lymphoma affecting the body cavities) and multicentric Castleman's disease. To date there is much evidence to support a direct role for HHV8 in kaposi's sarcoma.
• Synonyms: HHV-8, KHSV