CD283 / TLR3 Mouse Monoclonal Antibody [Clone ID: 1205C5F1 / TLR3.1]

CAT#: DDX0478A546-100

Reviews ()
Write a review

CD283 / TLR3 mouse monoclonal antibody, clone 1205C5F1 / TLR3.1


Product Datasheet for 'DDX0478A546-100'


USD 530.00


Availability*
2 Weeks

Size
    • 100 ug


Product images

Specifications

Product Data
Clone Name 1205C5F1 / TLR3.1
Applications FC, IHC, IP
Recommended Dilution FACS intracellular, ImmunoHistoChemistry paraffin sections, Immunoprecipitation.

Usage recommendation:

*This monoclonal antibody may be used between 5-20 μg/ml.
*Optimal dilution should be determined by each laboratory for each application.
*Coupled antibody: to maintain RT before using.
Reactivity Human
Host Mouse
Isotype IgG1
Clonality Monoclonal
Immunogen HEK-293 stably transfected with huTLR3+rhu TLR3 ECD (R&D)
Specificity Human TLR3.
Formulation Purified: 100 μg in 200μl / 50 μg in 100 μl Tris-NaCl pH 8.
Coupled: 100 μg in 200μl / 50 μg in 100 μl PBS 50% glycerol.
Label: Alexa Fluor 546
Concentration 0.5 mg/ml
Purification QMA Hyper D ion exchange chromatography
Conjugation Alexa Fluor 546
Background The Toll-like receptor (TLR) family are considered as key for sensing microbial infections and triggering inflammatory and innate responses. 3 novel mAbs were generated against TLR3 that support the emergence of an alternative model for TLR3 biology: TLR3 full-length (TLR3FL, 130KDa) corresponds to the TLR3 present in ER, which in resting cells is steadily converted within the Golgi into fully glycosylated TLR3 (TLR3FL+, 135KDa) and then rapidly cleaved by cathepsins in the endosome/lysosome into 2 long-lived associated fragments (72 KDa and 60KDa). (Toscano F et al, J. Immunol, 2013, 190: 764–773).
Synonyms Toll-like receptor 3
Reference Data
Customer Reviews 
Loading...
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
Antibody Performance Guarantee banner
ANTIBODY VALIDATION 101
Clone ID reveals the Source of Monoclonal Antibodies