LAMP3 Mouse Monoclonal Antibody [Clone ID: 104G4]

CAT#: DDX0190P-100

LAMP3 mouse monoclonal antibody, clone 104G4

Product Images

IHC staining of human lung frozen section with clone 104G4 (DX0190)

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  20h post GFP-SAO injection in the oral mucosa CD11b (green) and 104.G4 (red)

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  IHC on cryosection of human tonsil: double staining CD3 ( red) DC-LAMP 104G4 (blue)

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  Intracellular FACS staining of human monocytes cultured 24h with GM-CSF, IL4, LPS

Specifications

Product Data

• Clone Name: 104G4
• Applications: FC, IF, IHC
• Recommended Dilution: Intracyto Flow cytometry, IHC
• Reactivities: Human, Sheep
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: human DC-LAMP alkaline phosphatase fusion protein
• Specificity: human DC-LAMP (epitope in intracytoplasmic domain).
  Species cross-reactivity: Sheep
• Formulation: Tris-NaCl pH 8
  State: Purified
• Concentration: lot specific
• Purification: QMA Hyper D ion exchange chromatography
• Conjugation: Unconjugated
• Storage: -20°C. KEEP CONTENTS STERILE: no preservative.
  Purified antibodies: avoid repeated freeze/thaw cycles.
  Coupled antibodies: glycerol protects from freezing.
• Gene Name: lysosomal associated membrane protein 3
• Database Link:
  Entrez Gene 27074 Human
  UniProt ID Q9UQV4
• Background: The dendritic cell lysosomal-associated membrane protein (DC-LAMP)/CD208 is a type I integral transmembrane glycoprotein mostly homologous to CD68, of about 45 kDa in mouse and 90 kDa in human (glycosylation), with a bipartite C-terminal structure divided by a serine/proline rich region, a transmembrane domain and a conserved tyrosine-based lysosomal targeting motif in its cytoplasmic tail. Initially cloned as a specific marker of human mature dendritic cells (DCs), DC-LAMP has been subsequently shown to be expressed in alveolar type II pneumocytes. In both cell types, the molecule is found in the limiting membrane of intracellular multi-lamellar bodies, known as MIIC (MHC class II compartments) in human mature DCs and as lung surfactant-containing lamellar bodies in type II pneumocytes. In the latter cell type, DC-LAMP expression is also detected at the cell surface.
  (de Saint-Vis B et al, 1998 ; Immunity ; 9:325-336)
• Synonyms: DCLAMP, DC-LAMP, TSC403, Dendritic Cell Marker