MYBPC3 Mouse Monoclonal Antibody [Clone ID: OTI2F8]

CAT#: CF813807

Carrier-free (BSA/glycerol-free) MYBPC3 mouse monoclonal antibody, clone OTI2F8

Specifications

Product Data

• Clone Name: OTI1A5 OTI1C10 OTI1D1 OTI1D3 OTI1H1 OTI2D7 OTI2D8 OTI2D8D7 OTI2E7 OTI2F1 OTI2F2 OTI2F8 OTI3B1 OTI3E2 OTI3E6 OTI6F6 OTI7C4 OTI7C8 OTI7G2 OTI7H3 OTI9E4
• Applications: ELISA
• Recommended Dilution: ELISA 1:5000-10000
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Full length human recombinant protein of human MYBPC3（C0-C1） (NP_000247) produced in E.coli.
• Formulation: Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)
• Reconstitution Method: For reconstitution, we recommend adding 100uL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiment, we strongly recommend performing another round of desalting process. (OriGene recommends Zeba Spin Desalting Columns, 7KMWCO from Thermo Scientific)
• Purification: Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
• Conjugation: Unconjugated
• Predicted Protein Size: 140.8 kDa
• Gene Name: myosin binding protein C3
• Database Link:
  NP_000247
  Entrez Gene 4607 Human
  UniProt ID Q14896
• Background: MYBPC3 encodes the cardiac isoform of myosin-binding protein C. Myosin-binding protein C is a myosin-associated protein found in the cross-bridge-bearing zone (C region) of A bands in striated muscle. MYBPC3, the cardiac isoform, is expressed exclussively in heart muscle. Regulatory phosphorylation of the cardiac isoform in vivo by cAMP-dependent protein kinase (PKA) upon adrenergic stimulation may be linked to modulation of cardiac contraction. Mutations in MYBPC3 are one cause of familial hypertrophic cardiomyopathy. [provided by RefSeq, Jul 2008]
• Synonyms: CMD1MM; CMH4; cMyBP-C; FHC; LVNC10; MYBP-C

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Dilated cardiomyopathy, Hypertrophic cardiomyopathy (HCM)