Adenovirus (Hexon) Mouse Monoclonal Antibody [Clone ID: 2C4]

CAT#: BM907

Adenovirus (Hexon) mouse monoclonal antibody, clone 2C4, Purified

Specifications

Product Data

• Clone Name: 2C4
• Applications: ELISA, IF, WB
• Recommended Dilution: ELISA (1/20-1/200): Suitable as Capture antibody in a Sandwich ELISA with Product CatNo. BM908 as the Detection antibody.
  Immunofluorescence (1/10-1/50).
  Western blot (1/10-1/100).
• Reactivities: Adeno-associated Virus
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: ATCC VR5 virus
• Specificity: This Adenovirus antibody recognises the penton or hexon group antigen present in most ADV serotypes.
• Formulation: PBS containing 0.09% Sodium Azide as preservative.
  State: Purified
  State: Liquid purified IgG fraction.
• Concentration: lot specific
• Purification: Protein A Chromatography.
• Conjugation: Unconjugated
• Storage: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Background: Adenoviruses are DNA viruses generally widespread in nature that are frequently the cause of acute upper respiratory tract infections (i.e. common colds). Forty-seven known serotypes have been isolated since they were first discovered in 1953 with 3 types known to cause gastroenteritis. Several types have oncogenic potential though most cause self-limiting febrile illnesses characterised by inflammation of conjunctivae and the respiratory tract. The virus can be isolated from the majority of tonsils/adenoids surgically removed, indicating latent infections. It is not known how long the virus can persist in the body, or whether it is capable of reactivation after long periods. In patients experiencing immunosuppression (e.g. AIDS) it can be reactivated causing disease.
  Hexon protein is a major coat protein of adenoviruses. Adenoviruses capsids have three principal protein components: the hexon, the penton, and the fiber. Hexon consists of three subunits together forming two major components of different morphological symmetry. A triangular top with three towers of density is superimposed on a more bulky pseudo hexagonal base.