p53 (TP53) (16-25) Mouse Monoclonal Antibody [Clone ID: BP53-12]

CAT#: BM4079F

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p53 (TP53) (16-25) mouse monoclonal antibody, clone BP53-12, FITC


Product Datasheet for 'BM4079F'


 Cited in 3 publications.

USD 300.00


Availability*
2 Weeks

Size
    • 100 ug


Product images

Specifications

Product Data
Clone Name BP53-12
Applications FC, IF
Recommended Dilution Immunofluorescence: This conjugate is routinely tested by Flow Cytometry analysis using permeabilized transient wild-type p53-tranfectants.
Reactivity Human, Primate
Host Mouse
Isotype IgG2a
Clonality Monoclonal
Immunogen Bacterially expressed full-length wild-type p53.
Specificity This Monoclonal antibody BP53-12 recognizes defined epitope (aa 16-25) on Human p53, a 50 kDa tumour suppressor found in increased amounts in a wide variety of transformed cells. It is frequently mutated or inactivated in many types of cancer.
Formulation Phosphate buffered saline (PBS), pH~7.4
Label: FITC
State: Liquid purified Ig fraction
Preservative: 15 mM Sodium Azide
Label: Fluorescein Isothiocyanate. 
The reagent is free of unconjugated FITC.
Concentration 1.0 mg/ml
Conjugation FITC
Storage Store the antibody undiluted at 2-8 °C.
DO NOT FREEZE!
This product is photosensitive and should be protected from light.
Stability Shelf life: one year from despatch.
Background The tumour suppressor protein p53 is a key element of intracellular anticancer protection. It mediates cell cycle arrest or apoptosis in response to DNA damage or to starvation for pyrimidine nukleotides. It is up-regulated in response to these stress signals and stimulated to activate transcription of specific genes, resulting in expression of p21waf1 and other proteins involved in G1 or G2/M arrest, or proteins that trigger apoptosis, such as Bcl-2. The structure of p53 comprises N-terminal transactivation domain, central DNA-binding domain, oligomerisation domain, and C-terminal regulatory domain. There are various phosphorylation sites on p53, of which the phosphorylation at Ser15 is important for p53 activation and stabilization.
Synonyms Cellular tumor antigen p53, Tumor suppressor p53, Phosphoprotein p53, NY-CO-13
Reference Data

Citations (3)

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