Apolipoprotein A I (APOA1) Mouse Monoclonal Antibody [Clone ID: 1402]

CAT#: BM3300

Apolipoprotein A I (APOA1) mouse monoclonal antibody, clone 1402, Purified

Specifications

Product Data

• Clone Name: 1402
• Applications: ELISA, R
• Recommended Dilution: Competitive RIA or EIA.
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Purified human plasma Apo A-I
• Specificity: Detects Apolipoprotein AI.
  No cross reactivity with APO A-II or Apo B.
• Formulation: 0.015 M Potassium phosphate buffer, 0.15 M NaCl, pH 7.2 containing 0.09% sodium azide as preservative
  State: Purified
  State: Liquid purified Ig fraction
• Concentration: lot specific
• Purification: DEAE Chromatography
• Conjugation: Unconjugated
• Storage: Store the antibody at 2-8°C for one month or at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: apolipoprotein A1
• Database Link:
  Entrez Gene 335 Human
  UniProt ID P02647
• Background: Apolipoprotein A I promotes cholesterol efflux from tissues to the liver for excretion. Apolipoprotein A I is the major protein component of high density lipoprotein (HDL) in the plasma. Synthesized in the liver and small intestine, it consists of two identical chains of 77 amino acids; an 18 amino acid signal peptide is removed co-translationally and a 6 amino acid propeptide is cleaved post-translationally. Apolipoprotein A I is a cofactor for lecithin cholesterolacyltransferase (LCAT) which is responsible for the formation of most plasma cholesteryl esters. Defects in the Apolipoprotein A I gene are associated with HDL deficiency and Tangier disease.
  The therapeutic potential of apoA-I has been recently assessed in patients with acute coronary syndromes, using a recombinant form of a naturally occurring variant of apoA-I. The availability of recombinant normal apoA-I should facilitate further investigation into the potential usefulness of apoA-I in preventing atherosclerotic vascular diseases.
• Synonyms: APOA1, ApoA-I, Apo-AI, ApoAI