TrkB (NTRK2) pTyr706/Tyr707 Rabbit Polyclonal Antibody

CAT#: AP55777PU-N

TrkB (NTRK2) pTyr706/Tyr707 rabbit polyclonal antibody, Aff - Purified

Product Images

Immunohistochemical analysis of paraffin-embedded human brain tissue using Trk B (Phospho-Tyr706/Tyr707) antibody (left)or the same antibody preincubated with blocking peptide (right).

Specifications

Product Data

• Applications: IHC
• Recommended Dilution: Immunohistochemistry on paraffin sections: 1:50~1:100 .
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Peptide sequence around phosphorylation site of tyrosine 706/tyrosine 707 (T-D-Y(p)-Y(p)-R-V)derived from Human Trk B (KLH-conjugated)
• Specificity: The antibody detects endogenous levels of Trk B only when phosphorylated at tyrosine 706 and tyrosine 707.
• Formulation: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol
  State: Aff - Purified
  State: Liquid Ig fraction
• Concentration: lot specific
• Purification: Affinity chromatography using epitope-specific peptide
• Conjugation: Unconjugated
• Storage: Upon receipt, store undiluted (in aliquots) at -20°C.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Predicted Protein Size: 91 kDa
• Gene Name: neurotrophic receptor tyrosine kinase 2
• Database Link:
  Entrez Gene 4915 Human
  UniProt ID Q16620
• Background: Receptor for brain-derived neurotrophic factor (BDNF), neurotrophin-3 and neurotrophin-4/5 but not nerve growth factor (NGF). Involved in the development and/or maintenance of the nervous system. This is a tyrosine-protein kinase receptor. Known substrates for the TRK receptors are SHC1, PI-3 kinase, and PLC-gamma-1.
• Synonyms: TRKB, NTRK2