PERK (EIF2AK3) pThr981 Rabbit Polyclonal Antibody

CAT#: AP55771PU-N

PERK (EIF2AK3) pThr981 rabbit polyclonal antibody, Aff - Purified

Product Images

Immunohistochemical analysis of paraffin-embedded human prostate carcinoma tissue using PEK/PERK (Phospho-Thr981) antibody (left)or the same antibody preincubated with blocking peptide (right).

Specifications

Product Data

• Applications: IHC
• Recommended Dilution: Immunohistochemistry on paraffin sections: 1:50~1:100 .
• Reactivities: Human, Mouse
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Peptide sequence around phosphorylation site of threonine 981(A-R-H(p)-T-G) derived from Human PEK/PERK (KLH-conjugated)
• Specificity: The antibody detects endogenous levels of PEK/PERK only when phosphorylated at threonine 981.
• Formulation: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol
  State: Aff - Purified
  State: Liquid Ig fraction
• Concentration: lot specific
• Purification: Affinity chromatography using epitope-specific peptide
• Conjugation: Unconjugated
• Storage: Upon receipt, store undiluted (in aliquots) at -20°C.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Predicted Protein Size: 125 kDa
• Gene Name: eukaryotic translation initiation factor 2 alpha kinase 3
• Database Link:
  Entrez Gene 9451 Human
  UniProt ID Q9NZJ5
• Background: Phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2), leading to its inactivation and thus to a rapid reduction of translational initiation and repression of global protein synthesis. Serves as a critical effector of unfolded protein response (UPR)-induced G1 growth arrest due to the loss of cyclin-D1 (CCND1)
• Synonyms: PEK, PERK, HsPEK