TGF beta Receptor II (TGFBR2) pSer225/250 Rabbit Polyclonal Antibody

CAT#: AP55729PU-S

TGF beta Receptor II (TGFBR2) pSer225/250 rabbit polyclonal antibody, Aff - Purified

Product Images

Immunohistochemical analysis of paraffin-embedded human brain tissue using TGF β Receptor II (Phospho-Ser225/250) Antibody (left)or the same antibody preincubated with blocking peptide (right).

Specifications

Product Data

• Applications: IHC
• Recommended Dilution: Immunohistochemistry on paraffin sections: 1:50~1:100 .
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Peptide sequence around phosphorylation site of Serine 225/250(D-R-S(p)-D-I) derived from Human TGF β Receptor II (KLH-conjugated)
• Specificity: The antibody detects endogenous levels of TGF β Receptor II only when phosphorylated at serine 225/250.
• Formulation: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol
  State: Aff - Purified
  State: Liquid Ig fraction
• Concentration: lot specific
• Purification: Affinity chromatography using epitope-specific peptide
• Conjugation: Unconjugated
• Storage: Upon receipt, store undiluted (in aliquots) at -20°C.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Predicted Protein Size: 64 kDa
• Gene Name: transforming growth factor beta receptor 2
• Database Link:
  Entrez Gene 7048 Human
  UniProt ID P37173
• Background: Transmembrane serine/threonine kinase forming with the TGF-beta type I serine/threonine kinase receptor, TGFBR1, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis.
• Synonyms: TGF-beta receptor type-2, TGF-beta receptor type II, TGF-beta type II receptor, TbetaR-II, TGFR-2