CD32B (FCGR2B) pTyr292 Rabbit Polyclonal Antibody

CAT#: AP55706PU-S

CD32B (FCGR2B) pTyr292 rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot analysis of extracts from K562 cells treated with PMA using CD32 (Phospho-Tyr292) Antibody.The lane on the right is treated with the antigen-specific peptide.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: Western blot: 1:500~1:1000.
• Reactivities: Human
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Peptide sequence around phosphorylation site of tyrosine 292 (I-T-Y(p)-S-L) derived from Human CD32 (KLH-conjugated)
• Specificity: The antibody detects endogenous levels of CD32 only when phosphorylated at tyrosine 292.
• Formulation: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol
  State: Aff - Purified
  State: Liquid Ig fraction
• Concentration: lot specific
• Purification: Affinity chromatography using epitope-specific peptide
• Conjugation: Unconjugated
• Storage: Upon receipt, store undiluted (in aliquots) at -20°C.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Predicted Protein Size: 32 kDa
• Gene Name: Fc fragment of IgG receptor IIb
• Database Link:
  Entrez Gene 2213 Human
  UniProt ID P31994
• Background: Receptor for the Fc region of complexed or aggregated immunoglobulins gamma. Low affinity receptor. Involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B-cells. Binding to this receptor results in down-modulation of previous state of cell activation triggered via antigen receptors on B-cells (BCR), T-cells (TCR) or via another Fc receptor. Isoform IIB1 fails to mediate endocytosis or phagocytosis. Isoform IIB2 does not trigger phagocytosis.
• Synonyms: FCGR2B, FCG2, IGFR2, CDw32, Fc-gamma RII-b, Fc-gamma-RIIb, FcRII-b