Aromatase Rabbit Polyclonal Antibody

CAT#: AP54875SU-N

Aromatase rabbit polyclonal antibody, Serum

Specifications

Product Data

• Applications: ELISA, IHC, WB
• Recommended Dilution:

  ELISA.
  Western Blot: 1/200-1/2000.
  Immunohistochemistry: 1/50-1/500.

• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Synthetic peptide derived from C-terminal domain of P450 19A1
• Specificity: Reacts with 58 kDa Aromatase from Oryzias latipes (fish).
• Formulation: State: Serum
  State: Lyophilized serum
  Preservative: None
• Reconstitution Method: Restore in distilled water.
• Conjugation: Unconjugated
• Storage:

  Prior to reconstitution store the antibody at -20°C.
  Store reconstituted antibody at 2-8°C for one month or (in aliquots) at -20°C for longer
  Avoid repeated freezing and thawing.

• Stability: Shelf life: one year from despatch.

• Database Link:
  UniProt ID Q92087
• Background: CYP19A1 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids.This protein localizes to the endoplasmic reticulum and catalyzes the last steps of estrogen biosynthesis, three successive hydroxylations of the A ring of androgens. Mutations in this gene can result in either increased or decreased aromatase activity; the associated phenotypes suggest that estrogen functions both as a sex steroid hormone and in growth or differentiation.