ELOB (N-term) Rabbit Polyclonal Antibody

CAT#: AP54200PU-N

ELOB (N-term) rabbit polyclonal antibody, Aff - Purified

Product Images

TCEB2 Antibody (N-term) western blot analysis in mouse brain tissue lysates (35 ug/lane). This demonstrates the TCEB2 antibody detected the TCEB2 protein (arrow).

Specifications

Product Data

• Applications: WB
• Recommended Dilution: ELISA: 1:1;000.
  Western blot: 1:100~500.
• Reactivities: Human, Mouse
• Host: Rabbit
• Isotype: Ig
• Clonality: Polyclonal
• Immunogen: KLH conjugated synthetic peptide between 1-29 amino acids from the N-terminal region of human TCEB2
• Specificity: This antibody detects TCEB2 (N-term).
• Formulation: PBS
  State: Aff - Purified
  State: Liquid Ig fraction
  Preservative: 0.09% (W/V) sodium azide
• Concentration: lot specific
• Purification: Protein A column followed by peptide affinity purification
• Conjugation: Unconjugated
• Storage: Store at 2 - 8 °C for up to six months or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: transcription elongation factor B subunit 2
• Database Link:
  Entrez Gene 67673 MouseEntrez Gene 6923 Human
  UniProt ID Q15370
• Background:
  This gene encodes the protein elongin B, which is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene. Pseudogenes have been identified on chromosomes 11 and 13.
• Synonyms: Elongin 18 kDa subunit, Elongin-B, Elongin B, EloB
• Note: Molecular Weight: 13133 Da

Reference Data

• Protein Families: Druggable Genome, Transcription Factors
• Protein Pathways: Pathways in cancer, Renal cell carcinoma, Ubiquitin mediated proteolysis