RASA1 (C-term) Rabbit Polyclonal Antibody

CAT#: AP53583PU-N

RASA1 (C-term) rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot analysis of RASA1 / RasGAP (C-term) in 293 cell line lysates (35ug/lane). This demonstrates the RASA1 antibody detected the RASA1 protein (arrow).

Specifications

Product Data

• Applications: WB
• Recommended Dilution: ELISA: 1/1000.
  Western Blot: 1/100-1/500.
• Reactivities: Human
• Host: Rabbit
• Isotype: Ig
• Clonality: Polyclonal
• Immunogen: KLH conjugated synthetic peptide between 965-993 amino acids from the C-terminal region of Human RASA1 / RasGAP.
• Specificity: This antibody recognizes Human RASA1 / RasGAP (C-term).
• Formulation: PBS
  State: Aff - Purified
  State: Liquid purified Ig fraction
  Preservative: 0.09% Sodium Azide
• Concentration: lot specific
• Purification: Affinity Chromatography on Protein A
• Conjugation: Unconjugated
• Storage:

  Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.

• Stability: Shelf life: one year from despatch.

• Gene Name: RAS p21 protein activator 1
• Database Link:
  Entrez Gene 5921 Human
  UniProt ID P20936
• Background:
  The protein encoded by this gene is located in the cytoplasm and is part of the GAP1 family of GTPase-activating proteins. The gene product stimulates the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. Mutations leading to changes in the binding sites of either protein are associated with basal cell carcinomas. Alternative splicing results in two isoforms where the shorter isoform, lacking the N-terminal hydrophobic region but retaining the same activity, appears to be abundantly expressed in placental but not adult tissues.
• Synonyms: Ras GTPase-activating protein 1, GAP, Ras p21 protein activator, p120GAP, RASA, p120RASGAP
• Note: Molecular Weight: 116403 Da

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Axon guidance, MAPK signaling pathway