RAMP3 (C-term) Rabbit Polyclonal Antibody

CAT#: AP53574PU-N

RAMP3 (C-term) rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot analysis of RAMP3 Antibody Cat.-AP53574PU-N in NCI-H292 cell line lysates (35ug/lane). This demonstrates the RAMP3 antibody detected the RAMP3 protein (arrow).

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  Western blot analysis of RAMP3 Antibody Cat.-AP53574PU-N in Mouse kidney tissue lysates (35ug/lane). This demonstrates the RAMP3 antibody detected the RAMP3 protein (arrow).

Specifications

Product Data

• Applications: WB
• Recommended Dilution:

  ELISA: 1/1000.
  Western Blot: 1/100-1/500.

• Reactivities: Human, Mouse
• Host: Rabbit
• Isotype: Ig
• Clonality: Polyclonal
• Immunogen: Immunized with a KLH conjugated synthetic peptide between 90-118 amino acids from the C-terminal region of human RAMP3
• Specificity: This antibody recognizes Human and Mouse RAMP3 (C-term).
• Formulation: PBS
  State: Aff - Purified
  State: Liquid purified Ig fraction
  Preservative: 0.09% Sodium Azide
• Concentration: lot specific
• Purification: Protein A column, followed by peptide affinity purification
• Conjugation: Unconjugated
• Storage:

  Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.

• Stability: Shelf life: one year from despatch.

• Gene Name: receptor (G protein-coupled) activity modifying protein 3
• Database Link:
  Entrez Gene 56089 MouseEntrez Gene 10268 Human
  UniProt ID O60896
• Background: The protein encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus. RAMPs are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven transmembrane domains, can function as either a calcitonin-gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. In the presence of this (RAMP3) protein, CRLR functions as an adrenomedullin receptor.
• Synonyms: CRLR activity-modifying protein 3
• Note: Molecular Weight: 16518 Da

Reference Data

• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Vascular smooth muscle contraction