L1CAM (C-term) Rabbit Polyclonal Antibody

CAT#: AP52434PU-N

L1CAM (C-term) rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot analysis in Jurkat cell line lysates (35ug/lane) using CD171 / L1CAM antibody. This demonstrates the L1CAM antibody detected the L1CAM protein (arrow).

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  Western blot analysis in mouse cerebellum tissue lysates (35ug/lane) using CD171 / L1CAM antibody. This demonstrates the L1CAM antibody detected the L1CAM protein (arrow).

Specifications

Product Data

• Applications: WB
• Recommended Dilution: This antibody is suitable for Western blotting.
  The suggested dilution is: 1/100-1/500.
• Reactivities: Human, Mouse
• Host: Rabbit
• Isotype: Ig
• Clonality: Polyclonal
• Immunogen: Synthetic peptide - KLH conjugated - corresponding to the C-terminal region (between 1153-1182aa) of human CD171 / L1CAM.
• Specificity: This antibody detects CD171 / L1CAM at C-term.
• Formulation: PBS with 0.09% (W/V) Sodium Azide.
  State: Aff - Purified
  State: Liquid purified Ig fraction
• Concentration: lot specific
• Purification: Purified through a protein A column, followed by peptide affinity purification.
• Conjugation: Unconjugated
• Storage:

  Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.

• Stability: Shelf life: one year from despatch.

• Gene Name: L1 cell adhesion molecule
• Database Link:
  Entrez Gene 16728 MouseEntrez Gene 3897 Human
  UniProt ID P32004
• Background: L1CAM is an axonal glycoprotein belonging to the immunoglobulin supergene family. The ectodomain, consisting of several immunoglobulin-like domains and fibronectin-like repeats (type III), is linked via a single transmembrane sequence to a conserved cytoplasmic domain. This cell adhesion molecule plays an important role in nervous system development, including neuronal migration and differentiation. Mutations in the gene cause three X-linked neurological syndromes known by the acronym CRASH (corpus callosum hypoplasia, retardation, aphasia, spastic paraplegia and hydrocephalus). Alternative splicing of a neuron-specific exon is thought to be functionally relevant.
• Synonyms: N-CAM L1, CAML1, MIC5
• Note: Molecular Weight: 140003 Da

Reference Data

• Protein Families: Druggable Genome, ES Cell Differentiation/IPS, Transmembrane
• Protein Pathways: Axon guidance, Cell adhesion molecules (CAMs)