KDM4B (N-term) Rabbit Polyclonal Antibody

CAT#: AP52268PU-N

KDM4B (N-term) rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot analysis of JMJD2B Antibody (N-term) in A375 cell line lysates (35ug/lane). This demonstrates the JMJD2B antibody detected the JMJD2B protein (arrow).

Specifications

Product Data

• Applications: WB
• Recommended Dilution: ELISA: 1/1000.
  Western Blot: 1/100-1/500.
• Reactivities: Human
• Host: Rabbit
• Isotype: Ig
• Clonality: Polyclonal
• Immunogen: KLH conjugated synthetic peptide between 435-468 amino acids from the N-terminal region of human JMJD2B
• Specificity: This antibody recognizes Human JMJD2B / KDM4B (N-term).
• Formulation: PBS containing 0.09% (W/V) Sodium Azide as preservative
  State: Aff - Purified
  State: Liquid purified Ig fraction
• Concentration: lot specific
• Purification: Protein A column, followed by peptide affinity purification
• Conjugation: Unconjugated
• Storage:

  Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.

• Stability: Shelf life: one year from despatch.

• Gene Name: lysine demethylase 4B
• Database Link:
  Entrez Gene 23030 Human
  UniProt ID O94953
• Background:
  KDM4B is a histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a role in histone code. It does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20' and only able to demethylate trimethylated H3 'Lys-9', with a weaker activity than KDM4A, KDM4C and KDM4D. Demethylation of Lys residue generates formaldehyde and succinate.
• Synonyms: JHDM3B, KIAA0876
• Note: Molecular Weight: 121897 Da

Reference Data

• Protein Families: Druggable Genome