Artemis (DCLRE1C) (N-term) Rabbit Polyclonal Antibody

CAT#: AP51199PU-N

Artemis (DCLRE1C) (N-term) rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot analysis of Artemis Antibody (N-term) in Mouse heart tissue lysates (35ug/lane). DCLRE1C (arrow) was detected using the purified Pab.

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  Formalin fixed, paraffin embedded human lung carcinoma stained with Artemis Antibody (N-term) followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the DCLRE1C Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution:

  ELISA: 1/1000.
  Western Blot: 1/100-1/500.
  Immunohistochemistry on Paraffin Sections: 1/50-1/100.

• Reactivities: Human, Mouse
• Host: Rabbit
• Isotype: Ig
• Clonality: Polyclonal
• Immunogen: KLH conjugated synthetic peptide between 28~58 amino acids from the N-terminal region of Human DCLRE1C.
• Specificity: This antibody recognizes Human Artemis (N-term).
• Formulation: PBS
  State: Aff - Purified
  State: Liquid purified Ig fraction
  Preservative: 0.09% Sodium Azide
• Concentration: lot specific
• Purification: Affinity Chromatography on Protein A
• Conjugation: Unconjugated
• Storage:

  Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.

• Stability: Shelf life: one year from despatch.

• Gene Name: DNA cross-link repair 1C
• Database Link:
  Entrez Gene 227525 MouseEntrez Gene 64421 Human
  UniProt ID Q96SD1
• Background: DCLRE1C is a nuclear protein that is involved in V(D)J recombination and DNA repair. The protein has single-strand-specific 5'-3' exonuclease activity; it also exhibits endonuclease activity on 5' and 3' overhangs and hairpins when complexed with protein kinase, DNA-activated, catalytic polypeptide.
• Synonyms: DCLRE1C, ASCID, SCIDA, SNM1C, SNM1-like protein, A-SCID protein
• Note: Molecular Weight: 78436 Da

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Cell cycle, Non-homologous end-joining, Primary immunodeficiency