CTPS2 (C-term) Rabbit Polyclonal Antibody

CAT#: AP51128PU-N

CTPS2 (C-term) rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot analysis of CTPS2 (arrow) using rabbit polyclonal CTPS2 Antibody (C-term). 293 cell lysates (2ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the CTPS2 gene.

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  CTPS2 Antibody (C-term) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the CTPS2 antibody detected the CTPS2 protein (arrow).

Specifications

Product Data

• Applications: WB
• Recommended Dilution: ELISA: 1/1000.
  Western Blot: 1/100 - 1/500.
• Reactivities: Human
• Host: Rabbit
• Isotype: Ig
• Clonality: Polyclonal
• Immunogen: KLH conjugated synthetic peptide between 449-479 amino acids from the C-terminal region of human CTPS2
• Specificity: This antibody reacts to CTPS2.
• Formulation: PBS
  State: Aff - Purified
  State: Liquid purified Ig fraction
  Preservative: 0.09% (W/V) sodium azide
• Concentration: lot specific
• Purification: Affinity chromatography on Protein A
• Conjugation: Unconjugated
• Storage:

  Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.

• Stability: Shelf life: one year from despatch.

• Predicted Protein Size: 65678 Da
• Gene Name: CTP synthase 2
• Database Link:
  Entrez Gene 56474 Human
  UniProt ID Q9NRF8
• Background: The protein encoded by this gene catalyzes the formation of CTP from UTP with the concomitant deamination of glutamine to glutamate. This protein is the rate-limiting enzyme in the synthesis of cytosine nucleotides, which play an important role in various metabolic processes and provide the precursors necessary for the synthesis of RNA and DNA. Cancer cells that exhibit increased cell proliferation also exhibit an increased activity of this encoded protein. Thus, this protein is an attractive target for selective chemotherapy. Three alternatively spliced transcript variants encoding the same protein have been described for this gene.
• Synonyms: UTP-ammonia ligase 2, CTP synthetase 2, CTPS2

Reference Data

• Protein Pathways: Metabolic pathways, Pyrimidine metabolism