Centaurin gamma 1 (AGAP2) (C-term) Rabbit Polyclonal Antibody

CAT#: AP50861PU-N

Centaurin gamma 1 (AGAP2) (C-term) rabbit polyclonal antibody, Aff - Purified

Product Images

CENTG1 Antibody (C-term) western blot analysis in mouse brain tissue lysates (35ug/lane).This demonstrates the CENTG1 antibody detected the CENTG1 protein (arrow).

Specifications

Product Data

• Applications: WB
• Recommended Dilution: ELISA: 1/1000.
  Western blot: 1/100 - 1/500.
• Reactivities: Human, Mouse
• Host: Rabbit
• Isotype: Ig
• Clonality: Polyclonal
• Immunogen: KLH conjugated synthetic peptide between 850-877 amino acids from the C-terminal region of human CENTG1
• Specificity: This antibody reacts to CENTG1.
• Formulation: PBS
  State: Aff - Purified
  State: Liquid purified Ig fraction
  Preservative: 0.09% (W/V) sodium azide
• Concentration: lot specific
• Purification: Affinity chromatography on Protein A
• Conjugation: Unconjugated
• Storage:

  Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.

• Stability: Shelf life: one year from despatch.

• Predicted Protein Size: 124674 Da
• Gene Name: ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
• Database Link:
  Entrez Gene 216439 MouseEntrez Gene 116986 Human
  UniProt ID Q99490
• Background: GTPase-activating protein (GAP) for ARF1 and ARF5, which also shows strong GTPase activity. Isoform 1 participates in the prevention of neuronal apoptosis by enhancing PI3 kinase activity. It aids the coupling of metabotropic glutamate receptor 1 (GRM1) to cytoplasmic PI3 kinase by interacting with Homer scaffolding proteins, and also seems to mediate anti-apoptotic effects of NGF by activating nuclear PI3 kinase. Isoform 2 does not stimulate PI3 kinase but may protect cells from apoptosis by stimulating Akt. It also regulates the adapter protein 1 (AP-1)-dependent trafficking of proteins in the endosomal system. It seems to be oncogenic. It is overexpressed in cancer cells, prevents apoptosis and promotes cancer cell invasion.
• Synonyms: Centaurin-gamma-1, KIAA0167, GGAP2, PIKE

Reference Data

• Protein Pathways: Endocytosis