AKR1C4 (N-term) Rabbit Polyclonal Antibody

CAT#: AP50134PU-N

AKR1C4 (N-term) rabbit polyclonal antibody, Aff - Purified

Product Images

AKR1C4 Antibody (N-term) western blot analysis in NCI-H292 cell line lysates (35 ug/lane).This demonstrates the AKR1C4 antibody detected the AKR1C4 protein (arrow).

Specifications

Product Data

• Applications: WB
• Recommended Dilution: ELISA: 1/1000.
  Western blotting: 1/100 - 1/500.
• Reactivities: Human
• Host: Rabbit
• Isotype: Ig
• Clonality: Polyclonal
• Immunogen: KLH conjugated synthetic peptide between 10-39 amino acids from the N-terminal region of human AKR1C4.
• Specificity: This antibody reacts to AKR1C4.
• Formulation: PBS containing 0.09% (W/V) sodium azide as preservative
  State: Aff - Purified
  State: Liquid purified Ig fraction
• Concentration: lot specific
• Purification: Affinity chromatography on Protein A
• Conjugation: Unconjugated
• Storage: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: aldo-keto reductase family 1, member C4
• Database Link:
  Entrez Gene 1109 Human
  UniProt ID P17516
• Background: AKR1C4 is a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the bioreduction of chlordecone, a toxic organochlorine pesticide, to chlordecone alcohol in liver. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14.
• Synonyms: Chlordecone reductase, CDR, CHDR, 3-alpha-HSD1, Dihydrodiol dehydrogenase 4, DD4, DD-4, HAKRA
• Note: Molecular Weight: 37067 Da

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Androgen and estrogen metabolism, C21-Steroid hormone metabolism, Metabolic pathways, Metabolism of xenobiotics by cytochrome P450, Primary bile acid biosynthesis