MAPT / TAU Chicken Polyclonal Antibody

CAT#: AP32982SU-N

MAPT / TAU chicken polyclonal antibody, Ig Fraction

Product Images

Western blot of rat cortex lysate showing specific immunolabeling of the ~48, 65 & 75kda tau isoforms.

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  Immunofluorescence of cultured rat hippocampal neurons showing staining of Tau in red along the neuronal processes.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: Western blotting: 1/10,000.
  Immunohistochemistry.
  Immunofluorescence: 1/1000.
• Reactivities: Human, Rat
• Host: Chicken
• Isotype: IgY
• Clonality: Polyclonal
• Immunogen: Recombinant full length Human Tau expressed in and purified from E. coli.
• Specificity: Specific for the ~48, 65 & 75kDa Tau isoforms.
• Formulation: State: Ig Fraction
  State: Liquid Total IgY fraction
  Preservative: 10 mM Sodium Azide
• Conjugation: Unconjugated
• Storage: Store the antibody undiluted (in aliquots) at -20°C.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: microtubule associated protein tau
• Database Link:
  Entrez Gene 4137 Human
  UniProt ID P10636
• Background: Tau is a key microtubule-associated protein that plays an important role in the formation of microtubules in axons (Binder et al. 1985). Six tau isoforms have been identified as products of a single gene produced by alternative mRNA splicing (Goedert 1990). Tau mutations have been implicated in many neurodegenerative disorders such as Alzheimer’s disease (AD), Pick’s disease and progressive supranuclear palsy.
• Synonyms: MAPTL, MTBT1, Microtubule-associated protein tau, PHF-tau, Neurofibrillary tangle protein, Paired helical filament-tau